Opportunity to join a lab team developing the next generation of cellular immunotherapies. We are looking for an exceptionally motivated individual with past lab experience to join the lab of Dr. Eric Smith, Director of Translational Research, Immune Effector Cell Therapies at Dana Farber. The group is focused CAR T cell immunotherapy for cancer and protein engineering/synthetic biology; taking projects from conception, transgene design, genetic engineering, through reduction to practice, in vitro and in vivo studies, and ultimately translation to the clinic. >10 clinical trials have launched stemming from the Smith team’s preclinical work. The candidate will bring substantial in vivo experience with mouse models, ideally including tail vein injections. While a focus of the work in this role is on in vivo testing of the function of CAR T or other immunotherapies for cancer, you will have opportunity to learn/participate in molecular and cell biology methods. For example, mammalian cell culture, flow cytometry, viral transduction, generation of gene modified immune effector cells and testing their properties with in vitro functional assays. Dr. Smith is deeply committed to the success of each trainee that joins the lab. He believes that mentorship should be intentional, thought out, and personalized for each member of the group. He dedicates time to meet trainees' individual needs for scientific growth and pursuit of their career goals. We are looking for an enthusiastic, self-motivated, independent thinker with a tremendous work ethic. The position requires great planning and organizational skills, the ability to work well with others as part of a cohesive team. Initiative and creativity in problem solving are a must. science position will include project-specific and general lab duties as outlined below. The Dana-Farber Cancer Institute brings together world-renowned clinicians, innovative researchers and dedicated professionals, allied in the common mission of conquering cancer. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to all patients; we conduct research that advances treatment; we educate tomorrow’s physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. We are looking for an enthusiastic, self-motivated, independent thinker with a tremendous work ethic. The position requires great planning and organizational skills, the ability to work well with others as part of a cohesive team. Initiative and creativity in problem solving are a must. + This full-time bench science position will include project-specific and general lab duties as outlined below. + Intellectual input and co-authorship are encouraged. + Technical leadership of in vivo experimentation using current best practices. + Operational leadership and organization of in vivo experiments. + Examination of mice and specimens to detect the presence of disease or other health concern. + Contribute substantially toward progressing research projects. + Design and perform experiments both individually and collaboratively. + Maintains detailed electronic notebook, carefully documents samples, methods and observations. + Analyze experimental data and interpret results. Write reports and summaries of findings. Participate in formal and informal presentations of results. + Development, improvement and adherence to standard operating procedures. + Proactive and reliable stewardship of the laboratory. + Set up, adjust, calibrate, clean, maintain and troubleshoot equipment. + Maintain, clean and prepare supplies and work areas. + Participate in grant applications and manuscript preparation as required. + Intellectual commitment to position by keeping up with appropriate literature and actively participate in lab meetings, journal club and research seminars.https://ericsmithlab.dana-farber.org/ + Bachelor’s Degree OR Master’s Degree with a major in biology or chemistry preferred + Typically requires a minimum of 1-4 years related experience. + In vivo research lab experience in a full-time academic research lab or biotech/pharma is required. + Proficiency in procedures with murine models including tail vein injections. + Highly organized. + Learns and uses technical principles, processes, and concepts. + Follows standard practices and procedures + Builds stable working relationships, able to work with a wide range of faculty and staff. + **Exceptionally self-motivated and reliable.** + **Excellent written and verbal communication skills.** + Outstanding planning, organizational and multi-tasking skills. + **Must have attention to detail and be thorough in completing work tasks.** + Only applicants that submit a cover letter and a detailed CV will be considered. Cover letter should not be a reiteration of your CV, but focus on interests and career goals. Following a pre-screen interview, candidate will be requested to provide the contact information for three references.At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law. **EEOC Poster**