Johnson & Johnson in recruiting for a Sr. Principal Scientist, Cellular & Mechanistic Pharmacology located in Spring House, PA. At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/. For more than 130 years, diversity, equity & inclusion (DEI) has been a part of our cultural fabric at Johnson & Johnson and woven into how we do business every day. Rooted in Our Credo, the values of DEI fuel our pursuit to create a healthier, more equitable world. Our diverse workforce and culture of belonging accelerate innovation to solve the world’s most pressing healthcare challenges. We know that the success of our business – and our ability to deliver meaningful solutions – depends on how well we understand and meet the diverse needs of the communities we serve. Which is why we foster a culture of inclusion and belonging where all perspectives, abilities and experiences are valued and our people can reach their potential. At Johnson & Johnson, we all belong. The Discovery Technologies & Molecular Pharmacology (DTMP) team within Therapeutics Discovery contributes to the progression of drug discovery projects from target identification to clinical development. Join our team! We’re looking for a talented scientist with an immunology background, deep expertise in disease biology and cellular pharmacology, and a passion for finding innovative therapeutics to treat diseases with high unmet medical need. Key Responsibilities: + Lead development of innovative cell-based assays for immunology-focused projects to identify and evaluate targets, and to progress hits and lead molecules. + Act as a key liaison between DTMP and program teams, driving project strategy and execution, in partnership with cross-functional colleagues. + Lead efforts to combine translational and mechanistic assays with biosignature approaches and novel AI/ML methods to reveal new biology and pharmacology. + Manage and mentor lab scientists and contribute to the cellular and mechanistic pharmacology portfolio. + Analyze and present data at program team meetings, in-house seminars, leadership meetings and external scientific conferences, and publish research in high-quality journals. **Qualifications** Education: + Minimum of Ph. D. in Immunology, cell biology or equivalent with post-doctoral experience and a minimum of 10 years of experience developing and applying novel cellular assays in a pharmaceutical industry/biotech setting, is required. Experience and Skills: Required: + Proven track record in managing immunology-focused drug discovery programs across diverse modalities, in an industry setting. + Deep expertise and proven accomplishments in de novo immunology cellular pharmacology assay development, complex immune cellular models and high-throughput technology platforms. + Experience with generating and culturing translationally relevant cell models such as iPSC-derived cells, primary cells, and/or co-cultures. + Expertise collecting and analyzing data using high dimensional approaches such as high content imaging, flow cytometry and/or RNAseq. + Strong experience as a leader, problem solver and team collaborator able to facilitate understanding between biologists, chemists, and data scientists. + A demonstrated ability to apply novel approaches to address complex biology questions, as evidenced through strong peer-reviewed publications. + Excellent written communication, verbal communication, and oral presentation skills. + Demonstrated influence, negotiation, and conflict resolution skills. Preferred: + Expertise in assay automation. + Proficiency with CAS/CRISPR, lentivirus and/or RNAi approaches. + Expertise developing assays in advanced 3D cell models. + Expertise in neuroscience and/or oncology therapeutic areas. + Experience working with and/or guiding external collaborators in industry or academia. Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com.