We are looking for an experienced biochemist to participate in our exciting studies of the human protein kinome. As part of the largest BlueSky initiative, “Seeing the Invisible in Protein Kinases” at St. Jude Children’s Research Hospital, we are expanding our structural studies of the human kinome to identify novel kinase-binding ligands. We are looking for experienced Nuclear Magnetic Resonance (NMR) spectroscopist to aid in these efforts. The candidate will work in an exciting, fast-paced research environment as the candidate studies large and dynamic protein kinases by NMR spectroscopy. The unparalleled NMR center at St. Jude includes three 600 MHz, two 700 MHz, four 800 MHz, 850 MHz, and the first 1.1 GHz in the world. The research activity will be supported by Blue Sky initiative. This role will involve working closely as part of a multidisciplinary team including biochemists, structural biologists, computational chemists, and other biophysical specialists. St. Jude offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement, and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions: Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive. Key Responsibilities: Conduct experiments/projects independently under the overall direction of supervisor. Including construct design, chemical shift assignment, structure determination, and dynamics studies. Critically evaluate viability of kinase for dynamics and/or structural studies. Analysis of CEST relaxation profiles. Structure calculations using CYANA. Work closely with biochemist to produce samples. Train and oversee the work of others in NMR techniques and procedures associated with chemical shift assignment, structure determination, and dynamics studies. Independently troubleshoot, solve difficult problems, and propose solutions related to research project design and execution. Work effectively in a collaborative team environment where results are achieved through influence, cooperation, and the incorporation of multiple points of view. Ideal Candidate: Extensive experience in applying NMR techniques in characterization of the structure and dynamics of large proteins, including backbone and methyl assignment methodologies. Experience in using both automated and manual methods for assignment of both backbone and methyl groups. Experience in performing characterization of protein dynamics using CEST. Proficient in data processing using NMRPipe. Experienced in NMR structure calculation and refinement. Independently motivated, detail oriented and good problem-solving ability. Excellent organizational skills, with an ability to embrace change and multi-task in an extremely fast-paced environment. Excellent communications skills. Additional preferred skills: Proficiency in using nmr-fam Sparky, Bruker TopSpin, and CYANA. Experience using MAGIC algorithm for automated methyl assignments of methyl. Minimum Education/or Training: Bachelor's degree in relevant scientific area is required. PhD in NMR spectroscopy preferred. Minimum Experience: Ten (10) years relevant work experience is required with a Bachelor's degree. Eight (8) years of relevant work experience is required with a Master's degree. Five (5) years of relevant work experience is required with a PhD. Have More in Memphis Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis. From our world-renowned music scene to our eclectic mix of food and people. Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages. Plus, Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can “Have More in Memphis.” Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Senior Scientist - Nuclear Magnetic Resonance. Explore our exceptional benefits! Diversity, Equity and Inclusion St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.