Job Title: Senior Scientist, Gene Therapy Immunology

Grade: L2-2

Hiring Manager: Lavesh Gwalani

Location: Waltham, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress.

The Genomic Medicine Unit is seeking a highly motivated candidate with a strong background in Immunobiology for a Sr. Scientist role that will help build innovation in Gene Therapy Immunology.

Host immune response to non-viral gene therapy and adeno-associated viral vectors (AAV) is a key challenge for clinical adoption. The successful candidate will work transversally with members of various research groups including capsid engineering, large molecule research and computational biology teams to develop strategies aimed at minimizing adaptive immune responses to LNP and AAV. Working in this bench-research position, the candidate will explore the use of Sanofi’s proprietary immunomodulatory molecules to dampen host immunological response to gene therapy administration. Participation will provide the candidate a tangible opportunity to contribute to development of novel genomic medicine approaches for rare diseases with unmet need.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities

Play a key role in driving research efforts in testing Sanofi molecules in vivo and in vitro to determine immune modulation by these molecules with a focus on adaptive immune responses

Provide in vivo pharmacology expertise for the design and implementation of in vivo studies in mice and NHPs

Identify, develop and optimize / troubleshoot in vitro and / or ex vivo assays for determining adaptive immune responses to AAV and LNP in human/mouse/NHP primary cells

Responsible for independently executing experiments in a time sensitive manner

Develop and maintain a culture of teamwork and collaboration

About You

Basic Qualifications

Ph.D. in immunology or immunology-related discipline with 3+ years post-doctoral experience in immunology research

Demonstrated ability to design, execute, interpret, and present experimental results from in vivo studies and in vitro cell based assays for small molecules/biologics with immune-modulatory activity

Experience with developing and working with mouse models to evaluate immune responses.

Ability to manage multiple projects in parallel, communicate clearly and effectively and build open and collaborative relationships with scientists from multiple groups.

Flexibility to adapt to rapidly changing priorities and deadlines in a dynamic, fast paced work environment

Preferred Qualifications

Relevant industry experience / research background in immune modulation and/or immune tolerance

Experience with a range of in vivo skills, including but not limited to conventional routes of dosing administration and harvesting tissues and blood

Experience in identifying CRO resources, design and manage studies and establish strong capabilities in an outsourced setting

Why Choose Us?

Bring the miracles of science to life alongside a supportive, future-focused team.

Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.

At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.

Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com!

US and Puerto Rico Residents Only

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally inclusive and diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; natural or protective hairstyles; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.