Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche.

In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicine. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

Neuroscience & Rare Diseases represent a major focus area where we are committed to realizing our long-term vision of changing lives of patients with severe brain disorders. Our preclinical research and early clinical development activities center around large and rare indications. With unparalleled strengths across diverse disciplines, Roche is uniquely positioned to lead in transforming science into medicines for patients with disorders of the nervous system.

We are looking for a highly motivated Research Scientist to join our Neural Signalling Section in the Neuroscience & Rare Diseases Research Department in pRED at Roche in Basel. You will be embedded in a highly cross-functional drug discovery industry environment where you will establish and employ innovative biophysical, microfluidics, and biochemical technologies and workflows to perform target and drug discovery for neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and related proteinopathies.

Your impact

You plan, perform, and lead experiments, applications and work processes related to characterization of protein aggregates related to neurodegeneration at the micro- and nanoscale, either in situ in tissue and cells, ex vivo isolated or in vitro biochemically or synthetically generated,

You study and quantify the interaction of antibodies, peptides, small molecules or other molecular entities with proteins or protein aggregates by employing biophysical  and biochemical methods,

You establish and apply  novel work processes, and sensor technologies by employing existing in-house technologies or by integrating new ones from outside the company,

You work closely with different technologies and technology enabling labs within Roche to perform your tasks and to support specific drug discovery or biomarker projects,

You summarise regularly your experiments in written reports and in an electronic lab notebook and present your data and results to the lab, project teams and in department meetings,

You perform duties and take on general lab-related responsibilities within the research lab and the department.

For this, you will join a vibrant multicultural and cross-functional team of scientists, associates, postdocs and students working towards innovative approaches for drug discovery in nervous system and neuromuscular disorders. In that environment, you will be able to develop your leadership skills by occasionally training students and vocational trainees for a limited period of time and on specific methods. 

You hold a PhD or master's degree in Nanosciences, Biophysics/Physics, Structural Biology, or a related field

You bring confirmed experience in microfluidic protein isolation and analytical characterization using techniques such as Focal Molography, cryoWriter,  high-resolution cryogenic Transmission Electron Microscopy, Atomic Force Microscopy, and Surface Plasmon Resonance or Biolayer Interferometry. Additionally, the ability to apply Mass Spectrometry is highly desirable.

You possess expertise in binder screens, including DELT, antibody screens, or phage display, and have advanced training in immunostainings, microscopy, and digital data analysis, including code writing.

You have engineering and programming skills to improve microfluidic robots and enjoy pioneering technologies to integrate nanosciences with protein purification in drug discovery.

You are creative and problem-solving, bridging technical aspects of microfluidic robotic systems with protein analysis, and are proficient in planning, recording, and performing experiments.

You are self-organized, proficient in English communication, and driven by a mission to develop therapies for neurodegenerative disorders, demonstrating leadership and collaborative problem-solving skills.

Unwavering focus, collaborative teamwork and exceptional delivery are key behaviours that drive our mission of doing now what patients need next. Together, we can be transformative.

If you are passionate about contributing to a committed team and have the dedication to partnership and innovation, Roche is the place for you! Every role at Roche plays a part in making a difference in patients’ lives. 

Apply now and join us in making an impact!  

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.