Job Title: Research Scientist 
Location: San Diego, CA 
Type: Contract
Hourly Rate:  $49 - $53/hr 

Job Overview
Global Pharma company seeking a talented and self-motivated individual to join their Protein Production and Quality Attributes team within the Discovery Biotherapeutics group.  Candidates must bring a B.S. in biology, biochemistry or applicable sciences and +5 years of academic/industry experience OR a Masters Degree with 3+ years of academic/industry experience in biochemistry  Knowledge of purification and characterization of bispecific antibodies and complex molecules, executing challenging multi-step purification, analytical data interpretation, troubleshooting and formulation of final product is required.  Experience in automation of high-throughput purification is a plus.


Responsibilities Primary responsibility is to perform original research to develop marketable products. Special emphasis will be placed on automated antibody and bispecific purification, which will involve working with GE AKTA (Pure/Avant) and Unicorn software. Knowledge of Protein Maker instrument a plus. Generate mg to gram quantities of material for in-vivo efficacy studies. Develop and optimize high-throughput purification capabilities using Lynx900 and KingFisher Flex System. Packing of chromatography columns, operating endotoxin free chromatography, including operating preparative (FPLC) and analytical (HPLC) chromatography systems. Analytical characterization including endotoxin measurements, protein quantitation assays, analytical HPLC chromatography (HIC, SEC), capillary electrophoresis (CE-SDS and cIEF), DLS, and mass photometry. Buffer preparation, molar concentration quantitation and pH adjustment. Storing, inventorying, and ordering department supplies. Participates on cross-functional teams by performing assigned experiments and offering technical advice at team meetings; shares technical expertise with other colleagues; trains or provides guidance to other personnel, if needed.
   
Requirements Bachelor's Degree 5+ years of academic / industry experience
Or Master's Degree 3+ years of academic / industry experience Experience in antibody/bi-specific purification and characterization including, but not limited to SDS-PAGE, CE-SDS, CiEF, AnSEC, endotoxin measurement, A280. Automated liquid handling a plus. Sample inventory management. Benefits
System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.
 

System One, and its subsidiaries including Joulé, ALTA IT Services, TeamPeople, and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.

System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.