Regeneron is advancing its pipeline portfolio using a data-driven human translational approach. As part of this initiative, the Precision Medicine team is integrated with Discovery Research and Clinical Development teams to promote early adoption of biomarker strategy to guide clinical translation. The team collaborates with Clinical Sciences colleagues to develop the clinical experimental sciences (CES) studies for generating clinically testable, mechanistic hypotheses for each molecule, including developing scientific rationale for initial and new indications for PoC. Precision Medicine leads the biomarker strategy and execution to achieve proof of mechanism/concept in early clinical trials. The team also implements Precision Medicine strategies, including patient stratification and selection, to support late-stage clinical programs and companion diagnostics. Our team includes Precision Medicine Strategy Leads, Precision Medicine Operations specialists, as well as Quantitative Translation and Companion Diagnostics scientists. 

We are looking for a motivated individual who can conduct clinical data analysis in an open and collaborative working environment. This role will encompass exploratory analyses and visualization of transcriptomics, genomics, ctDNA, proteomics, imaging, and other biomarker data. This position also requires the development of tools and dashboards for querying, visualizing, and cleaning data. The individual will work collaboratively with internal and external groups to assure data integrity, best practices for analytics and data visualization, and offering strategic insights to drive Precision Medicine objectives.

As a Principal Scientist in Precision Medicine, a typical day may include the following: 

Drive analyses of exploratory biomarker data types across a range of exploratory studies

Lead the preparation of quality checked tables and graphs depicting research results for scientific presentations, manuscripts, and reports

Effectively communicate analytical plans and timelines for multiple concurrent projects with relevant study team members

Use both publicly available and self-built custom tools to integrate complex datasets

Perform statistical analysis on relevant clinical endpoints

Understand and implement data quality concepts and best practices. Identify data anomalies and work with data stewards in other units to perform root cause analysis on data quality issues

Maintain best coding and data cataloguing practices for business consistency and scientific reproducibility

Provide quantitative and computational expertise on data cleaning and visualization

This role may be for you if: 

You possess scientific creativity, attention to detail, and strong organizational skills

You are self-directed with the ability to work and operate independently within a tight deadline environment

You are agile and flexible in daily routines and are comfortable with staying on top of multiple projects

You have excellent interpersonal skills, both in person and over the phone 

In order to be considered for this position, you must have a Ph.D with a degree in Bioinformatics, Epidemiology, Human Genetics, Statistical Genetics, Biostatistics, Statistics, Computer Science, or Physics and 5 years with hands on experience. You should have relevant experience in statistical modeling and machine learning. A working knowledge of clinical trials are strongly preferred.  The candidate should have sound knowledge of statistical methodology; ability to critique devised hypotheses and results interpretation. Must be able to code in C/C++, java, python, and/or R and have demonstrated experience with feature selection-based machine learning techniques.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions.  For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process.  Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)