**Job Description** Title: Postdoctoral Fellow-MSH- Salary: 85,000 Department: Pathology, Molecular and Cell-Based Medicine. Physical work location: Molecular Microbiology Laboratory, 1428 Madison Avenue, Atran Building, #B215 New York, NY 10029-6574. Name PI or Supervisor: Alberto E. Paniz-Mondolfi MD, PhD. Web link to Department: https://www.mountsinai.org/patient-care/service-areas/pathology , https://www.mountsinai.org/patient-care/service-areas/pathology/clinical-services The consolidation of our state-of-the-art Molecular Microbiology Laboratory at Mount Sinai Hospital marks a significant milestone in our institution's commitment to advancing clinical diagnostics with a strong translational focus. With the primary objective of bridging the gap between cutting-edge research and practical applications, this laboratory is dedicated to addressing pressing clinical challenges posed by microbial pathogens. Leveraging advanced molecular techniques, we aim to develop and optimize rapid and accurate diagnostic assays for identifying a wide array of clinically significant microbial agents, including bacteria, viruses, and fungi. Through close collaboration with clinicians and healthcare professionals, our laboratory is poised to translate research findings into tangible solutions that directly impact patient care. We are dedicated to the systematic evaluation and validation of new diagnostic technologies (laboratory developed tests LDTs), ensuring their clinical utility and reliability. Moreover, by integrating genomics, pharmacogenomics transcriptomics, and proteomics, we seek to unravel the intricate interactions between pathogens and their hosts, thus shedding light on disease mechanisms and potential therapeutic targets. With a strong emphasis on translational research, our Molecular Microbiology Laboratory at Mount Sinai strives to make a meaningful difference in clinical diagnostics, ultimately improving patient outcomes and public health on a regional, national and global scale. **Qualifications** The Molecular Microbiology Laboratory at Mount Sinai Hospital is seeking a **Postdoctoral Fellow** to work on Infectious Diseases translational research and who is eager at exploring novel sequencing methods with a broader skill-set spanning both wet-laboratory skills and sequencing/computational approaches. The successful candidate should have doctorate (or PhD-level degree) and broad experience in microbiological and / or genetic diagnostics. Experience in bioinformatics is essential and desired. Key challenges will involve the design and refinement of rapid targeted and metagenomic genome sequencing approaches that could be deployed successfully into clinical laboratory diagnostics. Experience Required: + PhD in Biological Sciences, Biomedical Science or relevant fields. + At least 2 years of post-doctoral experience. + Established Academic (Professorship) background. + Experience in Molecular Biology. Genetics, Molecular Diagnostics and Laboratory Experimental Design. + Experienced in common and specialized molecular diagnostic techniques such as PCR, real-time PCR, next generation sequencing and bioinformatics. + Strong publication record in peer-reviewed journals. + Ability to work in a team and conduct independent research with good analytical, technical and problem-solving skills. **Compensation Statement** The Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for this role is $73,588.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits. SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 847 - Pathology, Molecular&Cell Based Medicine - ISM, Icahn School of Medicine The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.” **EOE Minorities/Women/Disabled/Veterans** **Responsibilities** The appointee will be responsible for initiating and carrying out validation of new diagnostic tests in the Molecular Microbiology Laboratory at the Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, under direct supervision of Dr. Alberto Paniz-Mondolfi (Director) and Juan David Ramirez (Assistant Director). Responsibilities/Goals/Outcomes of the Research Project: + Assist in designing, developing, executing, and implementing tests validation and/or development. (35%) + Perform specialized laboratory tests utilizing experimental protocols, which involves specialized procedures (Next Generation Sequencing and bioinformatics). (25%) + Prepare data summaries and keep detailed records of experiments. (20%) + Assists with the preparation of data for presentations at several meetings and for LDT submission. (20%) + May perform other duties and responsibilities as assigned or directed by the supervisor. This may include attendance of and participation in required training for role. Teach techniques to others, train, and mentor junior research staff. + Participate/assist in manuscript writing for publication in scientific journals and/or presentation; assist in grant writing. Technical Duties: (include any protocols) 1. Developing and optimizing molecular diagnostic assays for the rapid and accurate identification of clinically significant microbial pathogens, including bacteria, viruses, and fungi. 2. Evaluating and validating new diagnostic technologies and platforms for their clinical utility and accuracy. 3. Collaborating with clinicians and healthcare professionals to identify clinical needs and translate research findings into practical diagnostic and therapeutic solutions. 4. Implementing next-generation sequencing (NGS) techniques for metagenomic analysis of clinical samples to identify microbial communities and detect emerging pathogens. 5. Performing data analysis and bioinformatics to interpret NGS data and identify clinically relevant microbial signatures and genetic determinants of resistance. 6. Conducting large-scale epidemiological studies to investigate microbial outbreaks and monitor the prevalence of antimicrobial resistance. 7. Evaluating the performance of molecular diagnostic tests on clinical specimens and comparing them to existing diagnostic methods. 8. Integrating genomics, pharmacogenomics, transcriptomics, and proteomics data to understand host-pathogen interactions, disease mechanisms and response to antimicrobial treatment. 9. Assisting in the design and execution of clinical trials related to diagnostic test validation and performance assessment. 10. Participating in the development and validation of point-of-care diagnostic devices for resource-limited settings. 11. Collaborating with industry partners to facilitate the translation of research findings into commercial diagnostic products. 12. Contributing to the preparation of research grant proposals and funding applications to support translational research projects. 13. Publishing research findings in peer-reviewed journals and presenting at scientific conferences to disseminate knowledge and findings. 14. Mentoring and training graduate students and junior researchers on laboratory techniques and experimental procedures. 15. Ensuring compliance with regulatory requirements and ethical guidelines for human subject research in clinical diagnostics. The emphasis on clinical diagnostics and the translational component in this list reflects the integration of research findings into practical applications for improving patient care and public health outcomes. **About Us** **Strength through Unity and Inclusion** The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual. At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history. **About the Mount Sinai Health System:** Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally. **Equal Opportunity Employer** The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization. **Compensation Statement** Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.