Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through the Lerner Research Institute. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years. We are seeking a highly motivated postdoctoral fellow to join the Yu lab which focuses on cancer stem cell biology and mechanisms of therapeutic resistance at the Cleveland Clinic. Cancer stem cells reside in different niches including the perivascular and hypoxic niches. Our laboratory is interested in uncovering molecular mechanisms by which stemness in maintained in these different niches. We focus on glioblastoma, a primary brain tumor, and brain metastases. To this end, we utilize a combination of molecular biology and mouse modeling approaches. Because Dr. Yu is a physician-scientist, we aim to translate our research to the clinic. Applicants must have a PhD in cancer biology or related field and be highly motivated. For more information about our laboratory, please visit our website: https://www.lerner.ccf.org/cancerbio/yu/ . Interested applicants should send their application to yuj2@ccf.org . **Principal Investigator:** Jennifer Yu, MD, PhD **Lerner Research Institute Department:** Cancer Biology **Lab Research Topics:** + Glioblastoma + Cancer stem cells + Signal transduction + Non-coding RNAs + Microbiome + For more information about the lab's research, please visit: https://www.lerner.ccf.org/cancer-biology/yu/ (https://www.lerner.ccf.org/cancerbio/yu/) or contact Dr. Yu at yuj2@ccf.org . **Job Responsibilities:** + Independent project design with the goal of data generation, analysis, interpretation and manuscript preparation + Formulate and test hypotheses + Drug screening experience is helpful + Bioinformatics experience is helpful **Education:** + PhD or MD/PhD required + MD with relevant laboratory experience may substitute for PhD **Languages:** + English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status **Work Experience:** + Previous experience in a research or academic setting. Graduate student experience meets this requirement. + Scientific writing experience **Physical Requirements:** + Ability to perform work in a stationary position for extended periods + Ability to operate a computer and other office equipment + Ability to communicate and exchange accurate information + Ability to distinguish color + Manual dexterity to handle specimens and repair equipment + Ability to lift and transport equipment or specimens weighing up to 20 pounds + May be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc. **Personal Protective Equipment:** + PPE per institutional requirements; may vary by laboratory **Preferred Application Materials:** + **​** CV **Keywords:** Postdoc, Research, LRI, Glioblastoma, Brain tumor, Cancer stem cells, Hypoxia, Radiation, Microbiome, Signal transduction, lncRNA, Migration, Invasion, Drug screen, Therapeutic resistance Pay Range Minimum hourly: $0.01 Maximum hourly: $333,340.26 The pay range displayed on this job posting reflects the anticipated range for new hires. While the pay range is displayed as an hourly rate, Cleveland Clinic recruiters will clarify whether the compensation is hourly or salary. A successful candidate's actual compensation will be determined after taking factors into consideration such as the candidate's work history, experience, skill set, and education. This is not inclusive of the value of Cleveland Clinic's benefits package, which includes among other benefits, healthcare/dental/vision and retirement. Cleveland Clinic Health System is pleased to be an equal employment employer: Women / Minorities / Veterans / Individuals with Disabilities