Molecular Diagnostics Engineer - Point-of-Care Technologies

 

Key Responsibilities: 

Develop and Optimize Isothermal Amplification Technologies Design, implement, and validate novel isothermal DNA amplification methods Troubleshoot technical challenges in amplification efficiency and stability Engineer and Modify Enzymes for Diagnostic Applications Create customized enzyme variants with improved performance characteristics Establish robust protocols for enzyme production and quality control Design Advanced Molecular Detection Systems Create innovative signal amplification and detection strategies Integrate amplification chemistry with detection modalities Translate Laboratory Protocols to Point-of-Care Formats Adapt complex molecular methods to simplified, field-deployable formats Balance technical performance with usability requirements Lead Technical Innovation and Validation Direct research efforts to address critical performance challenges Collaborate with cross-functional teams to integrate technologies into product platforms  

Experience:

 

Advanced Expertise in Isothermal Amplification Technologies Demonstrated experience developing or optimizing isothermal amplification methods (LAMP, RPA, HDA, etc.) Hands-on experience troubleshooting complex molecular diagnostic challenges Enzyme Engineering and Characterization Experience modifying DNA/RNA polymerases or other enzymes for improved performance Demonstrable understanding of enzyme kinetics and biochemical optimization Background in protein engineering or directed evolution methodologies Point-of-Care Diagnostic Development Knowledge of sample preparation challenges and solutions for complex biological matrices Understanding of regulatory considerations for diagnostic development Single-Molecule Detection Methods Familiarity with nanopore technologies, fluorescence-based detection, or other single-molecule approaches Experience integrating molecular amplification with detection modalities Background in signal optimization and noise reduction strategies

 

Qualifications:

PhD in Molecular Biology, Biochemistry, Bioengineering, or related field Strong academic foundation in nucleic acid biochemistry and molecular diagnostics Research experience relevant to isothermal amplification technologies Proven expertise in enzyme manipulation and optimization Demonstrated ability to modify and enhance enzyme performance for specific applications Understanding of structure-function relationships in nucleic acid processing enzymes Publication record in molecular diagnostics or related fields First-author publications demonstrating technical innovation Evidence of contribution to advancement of diagnostic technologies Laboratory proficiency with advanced molecular techniques Mastery of nucleic acid extraction, amplification, and detection methodologies Hands-on skill with relevant analytical instruments and techniques Collaborative mindset with strong communication skills Ability to work effectively with multidisciplinary teams Experience translating complex technical concepts to diverse audiences Track record of successful cross-functional project contributions

 

Additional Points:

 

-- This is a full-time position with the potential title of Scientist, Senior Scientist, or Principal Scientist and the title is commensurate with experience and expertise.

-- This role is based in Maryland, with a comprehensive relocation package available.