The mission of The University of Texas MD Anderson Cancer Center is to eliminate cancer in Texas, the nation, and the world through outstanding programs that integrate patient care, research and prevention, and through education for undergraduate and graduate students, trainees, professionals, employees and the public.

The Core Director (CD)/Research Group Leader of the Proteomics Core will direct operations of the Proteomics Core to provide services, technology development, oversight, direction, and collaborations, and will work closely with the Scientific Director of the Proteomics Core. The CD will ensure this core facility enables breakthrough research to all MD Anderson and external users. The CD will discuss experimental design, guide suitable data analysis procedures, and assist with data interpretation to ensure high quality and reliable output derived from the Core technology. In addition to technically guiding core activities, the CD will work closely with the Scientific Director to ensure that the Proteomics Facility continues to innovate, adopt new technologies and analytical methods, and bring on new services to enable the Institution's research mission. It is anticipated that together with the Scientific Director leadership, the Proteomics Core will dedicate up to 20% of its activity to technology development, which is an integral part of the Core.

KEY FUNCTIONS RESEARCH ACTIVITIES

· Assist with identifying suitable approaches to deliver major key activities of the core, including protein identifications, post-translational modifications, immuno-peptidomics, and spatial proteomics, and ensure suitable bioinformatics and data analyses services are provided.

· Ensure that the core provides state-of-the-art proteomics service to enable MD Anderson's research mission in a range of biological matrices.

· Responsible for the development, validation, implementation, and execution of novel proteomics analytical methods to support, as much as technically and financially possible, the research required by MD Anderson investigators and other collaborators.

· Monitor experimental data quality and data release and capture, troubleshoot issues with

assay and instrument performance.

· Work with researchers and when needed with the Scientific Director to plan and execute proteomics studies, and trouble shoot any arising issues.

· Stay abreast of technical advances in terms of experimental methodologies, miniaturization, automation, and hardware developments. Evaluate the merits of the technical advances and implement these innovative solutions in the Core where appropriate.

· In coordination with the Scientific Director, seek to secure grant and foundation funding both for specific advanced research projects as well as for hardware refreshes.

· Interact with faculty members and their laboratory personnel to devise appropriate experimental strategies for data collection and analysis

· Consult with faculty on data quality and suggest strategies for improved sample quality

· Direct collaborative projects that require a high level of technical expertise or the application of new approaches

· Attend conferences, follow research literature, and discuss and establish new approaches with faculty

· Train and supervise facility staff members to maintain capabilities at the forefront of technological developments

· Assist with manuscript and grant preparation for collaborative research

· Maintain a safe, clean, and functional laboratory

ADMINISTRATIVE ACTIVITIES

· Oversee the installation, maintenance, and operation of current and future instrumentation and equipment

· Coordinate, direct and lead a team of successful internal proteomics experts as well as computational and analytical scientists. Train, supervise, mentor and performance manage the team to ensure optimal function of the Proteomics Core Facility.

· Complete the necessary documentation for any required formal reports.

· Work with computational and data scientists to ensure that the Core has appropriate IT solutions to support rapid data turnaround and reporting.

· Interact closely with MD Anderson faculty and trainees to ensure good usage of the facility and publish impactful research in high quality journals.

· Establish strong relationships with other proteomics researchers in Texas and across the Nation, and key relationships with the various instrument manufacturers.

· Be an integral part of the community of Core Directors at MD Anderson and seek to establish synergistic relationships with other core leaders.

· Carefully manage the financial operation of the core; design and implement business models and cross charges from users, bearing in mind the need to provide affordable technology to the core users.

· When required, engage in training of students, postdocs and other researchers on the

technology and suitable data analysis methods.

· Participate in choosing and purchasing equipment, and in the development of new infrastructure within the proteomics core facility

· Budget planning for service and maintenance, equipment modifications and improvements, and personnel

· Responsible for decisions on hiring, promotions, salary changes, performance evaluations, and terminations of focused team of scientists to aid in facility operations

· Responsible for presentation of the Core to site visitors

· Manage access to local and institutional computational infrastructure

· Establish scheduling policies for instrument access and workflows for equipment operation and usage

· Maintain accurate logs of equipment usage and performance

· Liaise with faculty advisory and oversight committees to ensure alignment with institutional needs

EDUCATIONAL ACTIVITIES

· Supervise equipment usage performed by principle investigators, researchers, post- docs, and graduate students

· Develop and implement \ educational and training programs for PIs and their staff

· Ensure facility users employ proper safety protocols

OTHER DUTIES AS ASSIGNED

Core Competencies

The position requires strong understanding in advanced proteomics, relevant data analysis skills, ability to interpret proteomics results and contribute to the design of follow-up experiments, troubleshoot issues with assay performance, and effectively communicate results and conclusions to the relevant scientists. Ability to work well under pressure and drive projects that affect critical timelines. Collaborative attitude is essential for this position. Required advanced skills and experience in:

• Analytic protein chemistry

• Mass spectrometry

• Proteomics

Education

Required: PhD in one of the natural sciences or related field.

Experience

Required: 7 years relevant research experience in laboratory to include three years of managerial experience.

Successful completion of the LEADing Self Accelerate and/or LEADing Self Discover programs may substitute for one year of required supervisory or management experience. Completion of both programs can be substituted for a maximum of two years of supervisory or management experience.

Preferred: Experience with mass spectrometry proteomics and implementation and development of new proteomics methodologies preferred. At least 5 years of postdoctoral training or equivalent time as a Staff Scientist. Technical Director of a core facility; Experience with cancer biology.

Must pass pre-employment skills test as required and administered by Human Resources.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

Additional Information
Requisition ID: 173906 Employment Status: Full-Time Employee Status: Regular Work Week: Days Minimum Salary: US Dollar (USD) 117,600 Midpoint Salary: US Dollar (USD) 146,500 Maximum Salary : US Dollar (USD) 176,400 FLSA: exempt and not eligible for overtime pay Fund Type: Soft Work Location: Onsite Pivotal Position: Yes Referral Bonus Available?: Yes Relocation Assistance Available?: Yes Science Jobs: Yes
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