At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$142,500 - $228,800

The ideal candidate will join an established computational ADME/Toxinformatics (cADMET) group within the multidisciplinary Drug Disposition organization. This group focuses on using groundbreaking in silico approaches to facilitate the extraction, sharing, and application of ADMET structure-property relationship (SPR) knowledge across program teams. The role involves actively engaging with various team members to identify issues and design innovative experiments that enhance the chances of achieving SAR improvements for successful clinical candidates. The candidate will maintain the existing in silico ADMET toolbox and innovate and implement new techniques and models as needed.

Are you ready to shape the future of drug discovery with your expertise in computational ADMET modeling? Apply today to join our innovative team at Lilly and make a real impact on advancing innovative therapies!

Job ResponsibilitiesIndependently research, develop, and deliver computational solutions to design and guide in vitro and in vivo experiments. Focus on enhancing scientific insights and decision-making knowledge.Conduct concerted data analysis to understand the connectivity across in silico, in vitro, and in vivo ADME and Safety data for project teams.Serve as a liaison to colleagues in ADME, Toxicology, PKPD, Discovery Chemistry, Computational Chemistry, Research IT, and Data Science for seamless integration of computational ADMET tools across the discovery research organization.Share and effectively communicate computational perspective within project teams to design rational, assumption-guided experiments and facilitate a multi-property optimization strategy.Use physiologically based pharmacokinetics (PBPK) principles for preclinical and clinical PK prediction to effectively drive projects toward successful proof of concept in the clinic.Basic RequirementsPhD in computational chemistry, cheminformatics, computational biology or a related field with more than 2 years of industry experience in developing and applying cheminformatics toolsAdditional PreferencesDemonstrated results/experience in working with interdisciplinary teams.Experience in applying advanced machine learning and statistical methodologies (e.g. uncertainty quantification, QSAR, etc.) for large scale data mining and modelingProficient in scripting/programming in one or more of the following languages: Python, C/C++, RWorking knowledge of principles of ADMET and pharmacokineticsProficiency in analyzing and visualizing multi-dimensional scientific dataProactive learning ability and independent problem-solving skillsSolid understanding of organic/medicinal chemistryFamiliarity in working with web-based applications, databases and automated workflow tools such as KnimeStrong communication skills

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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