**Working with Us** Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us . **Position Summary** We are looking for passionate graduate students who are seeking a six-month Co-op opportunity to learn, grow, and work alongside other talents. The Co-op participant will work in Computational Genomics (CG) under the guidance of an experienced scientist. Through the application of innovative bioinformatics tools and methods, CG is responsible for analyzing genomics NGS (Next Generation Sequencing) data sets generated from pre-clinical and clinical studies. These include RNA-Seq, Exome (WES) and Whole Genome Sequencing (WGS). CG interacts with and influences all aspects of R&D (Research & Development) at BMS, from early discovery through late-stage development. The Co-op will also provide an opportunity to gain an understanding of the drug development process through interactions with project teams and networking with individuals from multiple disciplines in BMS. The Co-op participant will have the opportunity to understand and contribute to various aspects of CG including NGS data analysis, development of computational pipelines and assist in expanding the teams NGS capabilities. **Key Responsibilities** The co-op program would play a crucial role in advancing the state-of-the-art in genomic analysis by integrating personalized and population-specific approaches into existing BMS WES and WGS pipelines. This would involve optimizing workflows, collaborating with multidisciplinary teams, and ensuring that these improvements lead to more accurate, comprehensive, and clinically relevant genomic analyses. A summary of some of the responsibilities include: + **Enhancing Variant Calling Accuracy** : Work on integrating pangenomic references, personalized genomes and imputation approaches into the variant calling pipelines to account for population-specific genetic diversity, leading to more accurate variant detection across different ethnicities and populations. + **Optimization of Personalized Genomic Analysis:** Generate personalized reference genomes based on individual genetic backgrounds. Implement and optimize up-to-date pipelines that utilize personalized genomes for variant calling, reducing biases and improving the detection of rare and complex variants. + **Tool Implementation and Automation of Workflows** : Adapt existing tools to incorporate pangenomic references, personalized genomes, and imputation approaches seamlessly into existing pipelines. + **Pipeline Automation and Optimization** : Optimize the computational performance of the WES and WGS pipelines, focusing on reducing runtime and computational resource usage while maintaining or improving accuracy. + **Data Analysis and Interpretation:** Understanding and showing the impact of improved variant calling identified through pangenomic and personalized genome approaches, focusing on clinically relevant biomarkers (Tumor Mutational Burden-TMB and Microsatellite Instability-MSI). + **Quality Control and Validation:** Perform benchmarking studies to compare the performance of the improved pipeline against traditional methods, focusing on sensitivity, specificity, and overall variant calling accuracy. Develop and implement quality control measures to ensure the reliability and reproducibility of the results generated by the pipeline. + **Collaboration and Cross-functional Communication:** Work closely with bioinformaticians, molecular biologists, and clinical geneticists to ensure that the improvements in the variant calling pipeline meet the needs of different stakeholders. Document the developed tools, methods, and workflows and provide training to other team members or end-users to ensure smooth implementation and adoption. **Qualifications & Experience** + Senior M.S. or Ph.D. graduate student in Bioinformatics, Computer Science or related field, no work experience required. + Fluency with Linux-based high-performance computing environments, including python, Linux shell scripting, R, ssh and git. + Experience with DNA-Seq and RNA-Seq pipelines and data a plus. + Experience with pipeline development and deployment via Docker, Common Workflow Language (CWL) a plus. + Some hands-on experience with common NGS tools (GATK, Picard, etc.) a plus. + Strong problem-solving and collaboration skills, and rigorous and creative thinking. + Excellent written and oral communication skills, including an ability to explain complex ideas to computational scientists, experimentalists, and clinicians. + The ability to collaborate with diverse groups across the organization and solve problems that will benefit downstream analysts and decision-making teams. If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. **Uniquely Interesting Work, Life-changing Careers** With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. **On-site Protocol** BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ (https://careers.bms.com/eeo-accessibility) eeo-accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/ Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. **Company:** Bristol-Myers Squibb **Req Number:** R1585571 **Updated:** 2024-11-04 03:01:23.547 UTC **Location:** Field Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.