The Epigenetics Group, a part of the Center for Applied Bioinformatics (CAB) at St. Jude Children's Research Hospital, is seeking a highly motivated and creative Bioinformatics Research Scientist or Lead Bioinformatics Analyst. This position involves developing and applying innovative analytical approaches to uncover the mechanisms driving pediatric cancers and other human diseases. By contributing to a wide range of projects and assisting researchers across St. Jude, you will make a meaningful impact on science and, ultimately, on the care and survival of pediatric cancer patients. In addition to performing diverse analytical tasks, we encourage team members to engage in pipeline development, explore novel trends in the field, stay updated on the latest methods, and even create new methodologies—provided these efforts align with our ultimate goal: “Finding cures. Saving children.™”. Our work often leads to high-profile publications, offering significant opportunities for career growth and scientific contributions. What We Offer: CAB provides a highly interactive and collaborative environment with opportunities to work alongside experts in transcriptomics, genomics, and genetics, as well as across basic and clinical research departments. Resources include but are not limited to: Access to St. Jude's high-performance computing clusters and cloud computing environments.Cutting-edge sequencing platforms, such as long-read sequencing technologies, single-cell DNA/RNA sequencing, and spatial transcriptomics. Innovative visualization tools and highly automated analytical pipelines powered by GPU technology. Mentorship from experienced scientists in data analysis and management, with an expertise in delivering high-quality results for competitive projects. Opportunities to participate in and present at scientific conferences, enhancing your expertise and expanding your network. CAB members have opportunities to contribute to high-impact research, co-author prominent publications, and file patents for novel biomarker discoveries or innovative methods in clinical diagnosis and treatment. Job Responsibilities: Independently perform basic and advanced level statistical analysis, algorithm implementation, programming from a variety of biotechnology platforms, and oversee quality check. Design and prepare materials and courses for training on various bioinformatics software and databases, computing, data mining, and analysis. Act as a liaison between end-users, software developers, system designers, and different departments. Establish protocols or best practices for common research tasks and SOP, evaluate products and solutions to make recommendations, and integrate solutions. Lead the development, implementation, installation, and maintenance of databases; coordinate data collection, database implementation, and usage and any hardware and software related to database collection. Develop programs to assist in the analysis of data within the databases. Assist in planning, coordinating, and organizing projects across departments and delegate tasks based on priority, expertise, and capacity. Perform other duties as assigned to meet the goals and objectives of the department and institution. Maintains regular and predictable attendance. Minimum Education and/or Training: Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field. Master's degree or PhD preferred. Minimum Experience: Minimum Requirement: Bachelor's degree with 6+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry). Experience Exception: Master's degree with 4+ years of relevant post-degree experience (OR) PhD with no experience. Experience in at least one programming or scripting language and at least one statistical package, with R preferred. Qualifications: Ideal candidates will have: Experience building, maintaining and optimizing analysis pipelines or installing tools for high-throughput next-generation sequencing data analysis (e.g., ChIP-Seq, ATAC-Seq, RNA-Seq, Hi-C, HiChIP, or Capture-C) in Linux/Unix environments. A solid understanding of basic epigenetic gene regulation mechanisms, like histone modifications, chromatin accessibility, DNA methylation or the 3D genome. Very good programming skills in Bash scripting language and Python (preferred) or R programming languages. Experience with version control systems such as Git. Strong communication and project managements skills. Experience with deep learning and Nextflow is a plus. This is an exceptional opportunity to gain experience in diverse areas of bioinformatics, contribute to cutting-edge research, and play a vital role in advancing St. Jude’s mission. Responsibilities Specific responsibilities may include NGS data quality control, multi-omics integrative analyses, data visualization, and the development and evaluation of analytic tools. Excellent communication skills are essential. You will collaborate closely with various St. Jude Principal Investigators and their research teams to provide standardized or customized analyses, utilizing St. Jude's high-performance computing clusters and cloud computing environments. Additional Requirements: Proficiency in programming (e.g., Python, R, C/C++, Perl, or other programming/scripting languages) in Linux/Unix environments is required. Proven ability to work effectively with a wide range of users. Demonstrated experience in analyzing and interpreting epigenetics data. Proven experience conducting independent data analyses and managing projects is required. Experience providing end-user support and training is required. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Bioinformatics Research Scientist- Epigenetics Group. Explore our exceptional benefits! Diversity, Equity and Inclusion St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.