SUMMARY/JOB PURPOSE:

The Bioinformatics Director has a key role in supporting the Exelixis early and late-stage portfolios. The responsibilities of this position include conducting computational analyses of preclinical, clinical, and translational datasets to identify potential predictive, prognostic and pharmacodynamic biomarkers.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

Obtain and analyze diverse public and internal datasets (e.g., microarray, RNA-Seq, WES, proteomic) to derive actionable insights.

Design and implement bioinformatics algorithms, including unsupervised and supervised machine learning, dynamic programming, and graph algorithms.

Conduct computational and statistical analyses to correlate patient subgroups with target expression and identify key pathways regulated by proprietary compounds.

Develop and apply novel computational approaches and analytical tools to address critical questions related to pipeline programs.

Collaborate with cross-functional teams, including discovery, translational medicine, and publishing to develop and execute biomarker studies.

Support biomarker data analysis and management, and serve as the data science lead for clinical studies.

Present results at internal and external meetings and collaborate to publish findings in high-quality journals.

SUPERVISORY RESPONSIBILITIES:

None

EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS:

Education/Experience:

PhD in the biology/bioinformatics or related discipline and a minimum of eight years of related experience; or, 

Equivalent combination of education and experience.

Experience/The Ideal for Successful Entry into Job:

Experience successfully managing bioinformatics projects in a biotech or academic environment.

Knowledge/Skills:

Strong analytical skills, able to critically assess, integrate and synthesize broad areas of scientific research from diverse sources to develop specific recommendations. A “differentiated” thinker with an ability to think beyond dogma.

Proven ability to work effectively in a collaborative environment and on cross-functional teams.

Ability to use broad expertise and to develop scientific strategies, company objectives and principles, and to achieve goals in creative and effective ways.

Ability to develop and maintain effective relationships with key external stakeholders and potential stakeholders.

Strong interpersonal, influencing, presentation, and written and verbal communication skills.

Ability to work both independently and collaboratively different stakeholders at Exelixis.

JOB COMPLEXITY:

Complex, involving critical input into decisions that can profoundly impact the company.

Works on extremely complex problems where analysis of situations or data requires an evaluation of intangible variables.

Exercises independent judgment in developing methods, techniques and evaluation criteria for obtaining results.

Uses professional concepts to contribute to development of company concepts and principles and to achieve objectives in creative and effective ways.

WORKING CONDITIONS:

This position requires 90% indoor work including significant time spent at a computer, analyzing data, writing reports, and collaborating with team members through on site and virtual meetings.

Approximately 10% travel is expected, primarily to attend and/or present at scientific meetings, workshops, and conferences.

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If you like wild growth and working with happy, enthusiastic over-achievers, you'll enjoy your career with us!

Our compensation reflects the cost of labor across several U.S. geographic markets, and we pay differently based on those defined markets. The base pay range for this position is $181,500 - $257,500 annually. The base pay range may take into account the candidate’s geographic region, which will adjust the pay depending on the specific work location. The base pay offered will take into account the candidate’s geographic region, job-related knowledge, skills, experience and internal equity, among other factors.

In addition to the base salary, as part of our Total Rewards program, Exelixis offers comprehensive employee benefits package, including a 401k plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Employees are also eligible for a discretionary annual bonus program, or if field sales staff, a sales-based incentive plan. Exelixis also offers employees the opportunity to purchase company stock, and receive long-term incentives, 15 accrued vacation days in their first year, 17 paid holidays including a company-wide winter shutdown in December, and up to 10 sick days throughout the calendar year.

DISCLAIMER 
The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification.  It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.