Performs a variety of moderately complex research tasks determined by the field and scope of the particular research project/study. Performs tasks related to the research project independently, but within broad guidelines and subject to periodic review by supervisor or other research staff. Technical Expertise Proficiency in fluorogenic aptamer design, including the development of light-up RNA/DNA aptamers. Strong understanding of fluorescence-based assays, fluorescence resonance energy transfer (FRET), or other fluorescence detection methods. Hands-on experience with high-throughput sequencing and bioinformatics pipelines for aptamer analysis. Skilled in molecular biology techniques such as cloning, in vitro transcription, PCR, and gel electrophoresis. Familiarity with RNA folding, secondary structure prediction, and related computational tools. Expertise in display-based selection techniques, including bead-based, droplet-based, or cell-based display platforms for aptamer screening. Proficiency in using fluorescence-activated cell sorting (FACS) for sorting small particles such as droplets or magnetic beads to identify and isolate high-affinity aptamers. Analytical and Problem-Solving Skills Strong critical thinking skills to troubleshoot experimental challenges and optimize protocols. Data analysis skills, including proficiency with tools like Python, R, or MATLAB for analyzing sequencing and fluorescence data. Preferred Skills Knowledge of autonomous laboratory workflows, such as liquid handling robotics or microfluidics, to improve aptamer selection efficiency. Minimum Education and/or Training: Bachelor’s degree in a relevant scientific area. Minimum Experience: 7 + years of research experience is required. 5 + years of research experience is required with a Master’s degree. 2 + years of research experience is required with a PHD. Experience leading and supporting research experiments preferred. Some experience leading lab and scientific project coordination, maintenance, and other research support activities preferred. Experience in guiding and training other laboratory personnel preferred. Proven performance in earlier role/comparable role. Eligibility for employees who transitioned into, were hired, or accepted offers for the role before 1/5/2025, the effective date of the Lab Research Career Path Refinements, will be determined based on the following criteria: Bachelor’s + 5 years; Master’s + 3 years; PHD + 0. Special Skills, Knowledge and Abilities: Results & Execution – Focus on setting high targets, following through with actions, and achieving results. Ability to anticipate roadblocks and circumvent challenges. Data analysis & Insights (Research) – Ability to set up data needs, collect, analyze, interpret scientific data and insights; stays abreast of data tools, and technologies in data analysis and insights. Industry & Regulatory Knowledge – Knowledge of industry best practices, Good Practices (GxP), regulatory compliance and documentation requirements relevant for scope of work. Lab Technology Expertise – Ability to leverage skills in routine/scientific/experimental procedures and lab techniques to identify/execute approaches and address scientific questions in research settings. Research Dissemination & Influence – Skills in conveying research findings to the appropriate audience using the right amount of data and narrative to enable decision-making. Ability to connect with influence critical stakeholders towards meaningful outcomes. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $65,520 - $114,400 per year for the role of Associate Scientist-Leading Florogenic Aptamer Selection Project. Explore our exceptional benefits! Diversity, Equity and Inclusion St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.