Site Name: USA - Pennsylvania - Upper Providence Posted Date: Jul 2 2024 An exciting opportunity is available for a highly motivated, creative, and meticulous lab-based scientist with a track record or interest in developing Complex In Vitro Models. The candidate will join the Complex In Vitro Models (CIVM) group within Target Discovery department in GSK’s research organization at the Upper Providence site. CIVM’s mission is to improve predictive and translational value of preclinical models. We strive to improve models to understand translational relevance of new targets, mechanism of action, efficacy, safety and metabolism, aiming to assess these in the same systems whenever possible, and ultimately to use these systems to refine, reduce, and replace animal models. The successful candidate will be responsible for developing, qualifying, and validating translational Complex in Vitro Models across the different phases of our drug discovery pipeline at GSK. Responsibilities Include: Develop and apply complex in vitro models using organoids and organ-on-a-chip approaches for mechanistic understanding and profiling of drug candidates across respiratory, neurology, hepatology, infectious disease, vaccines & oncology applications. Perform cell-based assays in combination with imaging technologies (e.g., confocal fluorescence), biochemical (e.g., ELISA, MSD) and molecular biology (e.g., RNA/DNA analysis) to support projects and different drug modalities. Support routine work in a matrix team and cross-functional environment to ensure optimal delivery of project and department objectives to the highest possible scientific standard. Write protocols, design and execute laboratory experiments, apply advanced data analysis, interpret data, compile reports, and communicate findings with an emphasis on providing appropriate context in order to progress projects and/or develop platforms. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: BS/MS degree in cellular/molecular biology and/or bioengineering or equivalent. 3+ years of laboratory experience. Experience in co-culture of vascular, stromal, immune and tissue cells. Experience with primary and iPSC derived cells. Preferred Qualifications: If you have the following characteristics, it would be a plus: Demonstrated experience of a broad range of cell biology and bioengineering techniques including complex co-cultures, organoid culture, and organ-on-chip technology. Experience in cellular characterization comprising of imaging, ELISA, MSD and omic analysis. Ability for clear, concise, and effective communication #LI-GSK Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. 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