At AstraZeneca, we win through science, it’s at the heart of our every success. That science is only possible when we all work together – we’ll always make sure you’re clear about how your role is connected to our wider mission to really show what science can do!  
 

We are seeking a Associate Director to join Integrated Bioanalysis organization to support Non-GXP bioanalysis and pharmacokinetic/toxicokinetic assessments by LC-MS for critical projects within AstraZeneca portfolio. 
 

Your primary responsibilities will include: 

Apply state-of-the-art mass spectrometry instrumentation to address sophisticated bioanalytical challenges related to drug discovery and development 

Development, validation/qualification of LC-MS assays in support of pharmacokinetic (PK), toxicokinetic (TK), Biomarker Quantification in variety of biological matrices 

Sample analysis for exploratory, GLP and clinical studies using automated and manual sample extraction platforms 

Perform data analysis on acquired datasets, collaborate with pharmacologists, statisticians, data scientists across global AstraZeneca teams 

Serve as bioanalytical expert on multidisciplinary project teams 

Adhere to established Standard Operating Procedures, industry practice and regulatory guidance as appropriate 

Contribute to validation/qualification protocols and reports, bioanalytical reports, clinical study reports, etc., as appropriate 

Demonstrate competency in troubleshooting, optimization and implementation of challenging and innovative LC-MS/MS assays 
 

Essential Requirements: 

For Associate Director: 

PhD in Chemistry, Biochemistry, Pharmaceutical Sciences or related scientific field 

7-10 years professional experience 

Background in analytical (bio)chemistry with emphasis on mass spectrometry applications in at least one of the following: PK of biologics (ADCs or Proteins), biomarker quantification, characterization and relative quantification for impurities/protein PTM 

Hands-on experience with chromatographic separation, characterization and quantification of various analytes by LCMS. 

Familiarity with triple quadrupole mass spectrometry instruments, experience with high resolution (HRMS, ToF or Orbitrap) is a plus; 

Proficiency with mass spectrometry software, data analysis software (Spotfire, R, MATLAB, JMP, etc.) word processing, and graphical computer programs 

Excellent organizational,  documentation and technical writing skills 

Excellent command of English (written and oral) 

Strong communication and interpersonal skills 

The ability to perform in a fast-paced, matrix-structured work environment. 

Strong publication/presentation record in analytical (bio)chemistry, bioanalysis, metabolomics/proteomics, or biomarker discovery 

Significant experience in method development, troubleshooting and complex bioanalytical methods 

Solid understanding of regulatory guidance on bioanalysis with GxP studies, white papers and industry standards for bioanalysis 

Experience serving as functional representative on multidisciplinary project teams with demonstrated ability to communicate complex data effectively to diverse audiences 

Experience managing/mentoring/supervising junior staff 

Pharmaceutical/biotech Industry experience 
 

Desirable Requirements 

Pharmaceutical/biotech Industry experience 

Familiarity with chromatographic assay validation guidelines, GLP/GXP regulations and fit-for-purpose validation principles 

Experience working in GLP-like/GLP/GMP settings 

Hands on experience with Sciex MS systems 

Hands on experience with reverse phase liquid chromatography (RPLC) 

Experience with protein labelling/LBA assay/magnetic bead based purification 

Experience with automated/semi-automated sample preparation 

Protein/ADC/macromolecule mass spectrometry experience 

Experience in bioanalysis/characterization of antibody-drug conjugates 
 

Benefits: 

AstraZeneca is a leading company in the healthcare industry, with a mission to enrich the lives of others. It’s our business to support healthy living, not only for our patients, but also for our employees. Our benefits program is flexible enough to meet employees’ varying needs, offers valuable choices, and is highly competitive. 

 
Why AstraZeneca? 

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. 

Come and join our journey - Apply today! 

The annual base pay (or hourly rate of compensation) for this position ranges from $127,626.40 - $191,439.60 USD Annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Where can I find out more? 

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/ 

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/ 

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en 

 

Date Posted

30-Oct-2024

Closing Date

29-Oct-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.