2025 Summer Intern – Translational Oncology, Maddalo Lab

Department Summary

The mission of the Translational Oncology department is to discover new targets and identify and characterize first- and best-in-class clinical candidates. We help guide clinical development of these drugs through a deep understanding of their unique mechanisms of action, define patient populations that are most likely to respond and biomarkers predictive of this response.

The Maddalo lab focuses on the investigation of mechanisms underlying therapy resistance and identification of drug combinations to prevent and/or delay adaptive and intrinsic resistance by leveraging CRISPR-mediated gene editing techniques and animal models of cancer.

This internship position is located in South San Francisco, on site.

The Opportunity

Interrogate therapeutic resistance using primary cell lines derived from novel mouse models of cancer.

Study underlying molecular mechanisms and drive rational drug combinations in vitro to overcome resistance

Design, execute, and interpret experiments and present data to scientists across the organization

Keep an accurate and timely record of research findings and progress.

Program Highlights

Intensive 12-weeks, full time (40 hours per week) paid internship.

Program start dates are in May/June 2025.

A stipend, based on location, will be provided to help alleviate costs associated with the internship.

Ownership of challenging and impactful business-critical projects.

Work with some of the most talented people in the biotechnology industry.

Final presentations of project work to senior leaders.

Lead or participate in intern committees to design and coordinate program events and initiatives.

Professional & personal development curriculum throughout the program, including networking opportunities, workshops, and panel discussions.

Participate in volunteer projects, social events, and team-building activities.

Who You Are (Required)

Required Education

You meet one of the following criteria:

Must be pursuing a PhD (enrolled student)

Required Majors: Cell Biology, Cancer Biology, Immuno-oncology, or related fields.

Required Skills:

Hands-on research experience in cell biology/cancer biology/biochemistry.

Knowledge of cancer signaling pathways and mouse models of cancer.

Experience in mammalian cell culture, molecular and cell biology techniques such as cell viability assays, western blotting, qRT-PCR, and flow cytometry.

Ability to work independently in a collaborative environment.

Highly motivated and eager to contribute scientifically to a fast-paced research program.

Preferred Knowledge, Skills, and Qualifications

Familiarity CRISPR-Cas9 genome editing and next-generation sequencing techniques, such as bulk and single cell RNA-sequencing is preferred but not required.

Excellent communication, collaboration, and interpersonal skills.

Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion.

Along with the submission of your CV, a cover letter is optional.

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of California is $45.00 hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits.

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